Dedicated to my Mom. 

Chili pepper is the fruit of plants from the genus Capsicum, members of the nightshade family, Solanaceae.

Chili peppers originated in the Americas and have been a part of the human diet in the Americas since at least 7500 BC. There is archaeological evidence at sites located in southwestern Ecuador chili peppers were domesticated more than 6000 years ago and is one of the first cultivated crops in the Americas that is self-pollinating.

Christopher Columbus was one of the first Europeans to encounter them in the Caribbean and called them "peppers" because of their similarity in taste with the Old World black peppers of the Piper genus.

Chilies were cultivated around the globe after Diego Αlvarez Chanca, a physician on Columbus' second voyage to the West Indies in 1493, brought the first chili peppers to Spain, and first wrote about their medicinal effects in 1494.
From Mexico, at the time the Spanish colony controlled commerce with Asia, chili peppers spread rapidly incorporated into the local cuisines in the Philippines and then to India, China, Korea and Japan.

The substances that give chili peppers intensity when ingested or applied topically are capsaicin (8-methyl-N-vanillyl-6-nonenamide) and several related chemicals, collectively called capsaicinoids. Capsaicin is the primary ingredient in pepper spray.

When consumed, capsaicinoids bind with pain receptors in the mouth and throat that are responsible for sensing heat. Once activated by the capsaicinoids, these receptors send a message to the brain the person has consumed something hot. The brain responds to the burning sensation by raising the heart rate, increasing perspiration and release of endorphins. A 2008 study reports capsaicin alters how the body's cells use energy produced by hydrolysis of ATP. In the normal hydrolysis the SERCA protein uses this energy to move calcium ions into the sarcoplasmic reticulum. When capsaicin is present, it alters the conformation of the SERCA, and thus reduces the ion movement; as a result the ATP energy stimulates the body’s burning of fat by increasing the metabolism of the body’s adipose tissue, generating heat helping to lose weight.

The "heat" of chili peppers is measured in Scoville heat units (SHU), which is the number of times a chili extract must be diluted in water for it to lose its heat. Bell peppers rank at 0 SHU, New Mexico green chilis at about 1,500 SHU, jalapeρos at 3,000–6,000 SHU, and habaneros at 300,000 SHU. The record for the hottest chili pepper was assigned by Guinness World Records to the naga jolokia (from northeastern India), measuring over 1,000,000 SHU. Pure capsaicin, which is a hydrophobic, colorless, odorless, and crystalline-to-waxy solid at room temperature, measures 16,000,000 SHU.

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